• Colorectal Cancer Info MAIN MENU
  • Screen MAIN MENU
  • Care MAIN MENU
  • Cure MAIN MENU
  • Get Involved MAIN MENU
  • Our Mission MAIN MENU

Subscribe to the Newsletter

What is Muir-Torre Syndrome?

Muir-Torre Syndrome (MTS) is a subtype of Lynch syndrome. It is an inherited condition that increases a person’s lifetime risk for developing rare types of skin cancer, gastrointestinal tract cancers (mostly colorectal cancer), and genitourinary tract cancers.

Like in Lynch syndrome, MTS is caused by an inherited harmful change (mutation) in one of the DNA mismatch repair (MMR) genes. The mutation is passed from one generation to the next, and in a family with a parent who has an inherited change in their DNA, each child has 50% of being diagnosed with MTS.

The MLH1 and MSH2 genes are most commonly mutated in MTS patients.

What are the symptoms of MTS?

The presence of specific types of skin or internal cancers are the primary symptom of MTS.

Skin Cancers

  • Sebaceous adenoma is the most frequent symptom in people with MTS (80-99%).
  • Sebaceous carcinoma of the eyelid is an aggressive cancer that spreads to the eye orbit and can be fatal.
  • Additional skin cancers include sebaceous epitheliomas and keratoacanthomas.

Internal Cancers

  • 30-79% of MTS patients have colon cancer or stomach cancer.
  • 5-29% of MTS patients have endometrial or breast cancer.
  • About 60% of people with MTS develop metastatic disease.

Family history overview

Learn about the role family history plays when it comes to colorectal cancer prevention and screening. 

What is FAP syndrome?

Learn more about familial adenomatous polyposis (FAP), an inherited disorder characterized by cancer of the colon and rectum.

Latest Updates

Upcoming Events

Are you sure?

Clicking "Start Over" will empty your resources drawer and take you back to the beginning of the journey customizer. Would you like to continue?

Are you sure?

Clicking "Exit" will permanently close your resource drawer for the rest of the session. If you would like to minimize the drawer and access it from other pages, click the symbol next to "MY RESOURCES". Would you like to permanently exit the drawer?