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In a critical step forward in the mission to end colorectal cancer, the Colorectal Cancer Alliance has announced Project Cure CRC. The initiative reflects the Alliance’s renewed effort to fund tens of millions of dollars in expedited, novel colorectal cancer research over the next two years.

With this bold and urgent undertaking, the Alliance seeks to create major breakthroughs in colorectal cancer diagnosis, treatment, metastasis, and survivorship. Project Cure CRC resources will support investigators dedicated to colorectal cancer research and will help fuel leading-edge studies, clinical trials, and collaborations to drive progress toward more effective and personalized treatments for colorectal cancer patients. The fund will catapult a radical new endeavor aimed at discovering innovative advancements and ultimately a cure for the disease.

The First Project 

The first $1.6 million of a substantially larger investment will fund research by Raghu Kalluri, M.D., Ph.D., at The University of Texas MD Anderson Cancer Center.

His project aims to develop urgently needed therapeutic options for the 96% of colorectal cancer patients with microsatellite stable (MSS). Current CRC treatments for these patients have long-term surgical and/or toxic side effects that greatly impact the quality of life of survivors. In addition, patients tend to develop resistance to therapy over time, leaving them out of therapeutic options.

This research will seek novel and effective therapeutic options that can be developed rapidly.

Kalluri Discusses His Research

Raghu Kalluri, MD, PhD, shares how his research will improve treatment for a "large percentage of patients who do not have many options." 


Project Cure CRC Co-Chairs

Michael Sapienza
CEO, Colorectal Cancer Alliance

Katie Chudnovsky
Board Member, Colorectal Cancer Alliance 

Alliance Project Lead

David Fenstermacher, PhD
Senior Director of Research and Medical Affairs, Colorectal Cancer Alliance 

Scientific Co-Chairs

John Marshall, MD
Georgetown University

Scott Kopetz, MD, PhD, FACP
MD Anderson Cancer Center

Christopher Lieu, MD
University of Colorado Cancer Center

Patient Advocate Co-Chair

John Woerner
mCRC Survivor and Board Member, Colorectal Cancer Alliance 

Grant Review Committee

J. Randolph Hecht, MD
UCLA Health

Scott Kopetz, MD, PhD, FACP
MD Anderson Cancer Center

Christopher Lieu, MD
University of Colorado Cancer Center

John Marshall, MD
Georgetown University

Alan P. Venook, MD
UCSF Health

Support the Project

The Colorectal Cancer Alliance invites the public, corporations, foundations, and philanthropic individuals to join us by contributing to Project Cure CRC.

Submit Proposals

Researchers interested in learning how to submit proposals for potential funding can email research@ccalliance.org.

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