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Supporting Innovative Research


The Alliance’s mission is to end colorectal cancer in our lifetime. By supporting innovative colorectal cancer research by top doctors and scientists, we take important steps toward realizing our vision — a world free of this disease.

Click on a type of research below to see who is using our funding to accelerate treatment, prevention, and a cure. 

Research Focus: Health Disparities

Dr. Kishore Guda

Decoding Molecular Programs Contributing to Colorectal Cancer Disparities

Institutions: Case Comprehensive Cancer Center, Digestive Health Research Institute
Funding Mechanism: Chris4Life
Research Description: Dr. Kishore Guda aims to characterize the molecular profiles of colorectal cancers in African American versus European American patients. The investigators have accrued large numbers of colorectal cancer samples from African American and European American patients and have established relevant cancer cell and mouse models in the laboratory. Using these unique resources and methodologies, Dr. Guda and his team will discover and validate biologic mechanisms likely contributing to colorectal cancer health disparities. Importantly, the study is designed to decode the role of tumor biology as well as socio-demographic factors that jointly contribute to racial disparities in colorectal cancer outcomes. Overall, their studies will inform the development of new biomarkers and therapeutic strategies with the overarching goal of improving health equity in colorectal cancer.

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