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Chemotherapy


Approved chemotherapies for colorectal cancer (colon or rectal cancer).

Approved chemotherapy combinations

  • CapeOx (Capecitabine and oxaliplatin)

    CapeOx is a chemotherapy regimen of capecitabine and oxaliplatin. Capecitabine is given orally and oxaliplatin is given through injection or IV into a port in your chest.

    Cape = Capecitabine
    Ox = Oxaliplatin

    COMMON SIDE EFFECTS

    • Diarrhea
    • Loss of appetite, nausea and/or vomiting
    • Mouth sores
    • Anemia
    • Pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet (hand-foot syndrome)
    • Numbness, burning, and tingling in the hands or feet from nerve damage (peripheral neuropathy), cold sensitivity in the extremities and oral cavity
  • FOLFIRI (5-FU, leucovorin and irinotecan)

    FOLFIRI is a chemotherapy regimen of several different drugs and leucovorin. It is typically given through injection or IV into a port in your chest.

    FOL = Leucovorin Calcium (Folinic Acid)F = FluorouracilIRI = Irinotecan

    COMMON SIDE EFFECTS

    • Diarrhea

    • Fatigue and weakness

    • Loss of appetite, nausea and/or vomiting

    • Risk of infection

    • Mouth sores and ulcers

    • Hair thinning or loss

     

    DOWNLOAD: 5FU SYMPTOMS VS SIDE EFFECTS

  • FOLFOX (5-FU, leucovorin and oxaliplatin)

    FOLFOX is a chemotherapy regimen of several different drugs and leucovorin. It is typically given through injection or IV into a port in your chest.

    FOL = Leucovorin Calcium (Folinic Acid)
    F = Fluorouracil
    OX = Oxaliplatin

    FDA APPROVED

    2004

    COMMON SIDE EFFECTS

    • Risk of Infection
    • Diarrhea
    • Mouth sores
    • Fatigue
    • Pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet (hand-foot syndrome)
    • Numbness, burning, and tingling in the hands or feet from nerve damage (peripheral neuropathy), cold sensitivity in extremities and oral cavity

     

    DOWNLOAD: 5FU SYMPTOMS VS SIDE EFFECTS

  • FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)

    FOLFOXIRI is a chemotherapy regimen of several different drugs and leucovorin. It is typically given through injection or IV into a port in your chest.

    FOL = Leucovorin Calcium (Folinic Acid)
    F = Fluorouracil
    OX = Oxaliplatin
    IRI = Irinotecan

    FDA APPROVED

    2014

    COMMON SIDE EFFECTS

    • Risk of Infection
    • Diarrhea
    • Hair loss or thinning
    • Mouth sores
    • Fatigue
    • Hand-Foot Syndrome – peeling skin on your hands or feet, pain, tenderness, redness, swelling, blistering
    • Peripheral Neuropathy – numbness, burning, and tingling in the hands or feet from nerve damage, cold sensitivity in extremities and mouth. Cannot drink anything cold.

     

    DOWNLOAD: 5FU SYMPTOMS VS SIDE EFFECTS

Approved chemotherapy drugs for colorectal cancer

  • Eloxatin (Oxaliplatin)

    Oxaliplatin is a chemotherapy drug typically used in combination with 5-fluorouracil and leucovorin or capecitabine to treat colorectal cancer. It is administered by IV and stops cancer cell growth and slows the spread of cancer cells in the body.

    FDA APPROVED

    2002

    COMMON SIDE EFFECTS

    • Diarrhea
    • Loss of appetite, nausea and/or vomiting
    • Mouth sores
    • Numbness, burning, and tingling in the hands or feet from nerve damage (peripheral neuropathy), sensitivity to cold in extremities and oral cavity
  • Xeloda (Capecitabine)

    Xeloda is a chemotherapy drug typically administered in pill form and taken every day for two weeks. This may be repeated as directed by a doctor. Xeloda works by slowing or stopping cancer cell growth and by decreasing tumor size. Xeloda is similar in action to 5-FU and can be used in place of 5-FU and leucovorin.

    FDA APPROVED

    2001

    COMMON SIDE EFFECTS

    • Diarrhea
    • Loss of appetite, nausea and/or vomiting
    • Weakness, feeling light-headed, hot or dry skin
    • Pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet (hand-foot syndrome)
    • Fever
    • Anemia
    • Risk of infection

    DOWNLOAD: 5FU SYMPTOMS VS SIDE EFFECTS

  • Camptosar (Irinotecan/CPT-11)

    Irinotecan is a chemotherapy drug that can be administered through an injection or port, which puts the drugs directly into a large vein in the chest.

    Irinotecan blocks an enzyme in cells called topoisomerase I. Cells need this enzyme to divide and grow. When the enzyme is blocked by irinotecan, the cell’s DNA gets tangled up and the cell can’t divide. Since cancer cells divide faster than normal cells, they are more likely than normal cells to be affected by irinotecan.

    FDA APPROVED

    1996

    COMMON SIDE EFFECTS

    Diarrhea
    Fatigue and weakness
    Loss of appetite, nausea and/or vomiting
    Risk of infection
    Mouth sores and ulcers
    Hair thinning or loss

  • 5Fluorouracil (5-FU)

    Irinotecan is a chemotherapy drug that can be administered through an injection or port, which puts the drugs directly into a large vein in the chest.

    Irinotecan blocks an enzyme in cells called topoisomerase I. Cells need this enzyme to divide and grow. When the enzyme is blocked by irinotecan, the cell’s DNA gets tangled up and the cell can’t divide. Since cancer cells divide faster than normal cells, they are more likely than normal cells to be affected by irinotecan.

    FDA APPROVED

    1996

    COMMON SIDE EFFECTS

    • Diarrhea
    • Fatigue and weakness
    • Loss of appetite, nausea and/or vomiting
    • Risk of infection
    • Mouth sores and ulcers
    • Hair thinning or los
  • Lonsurf (TAS-102)

    Lonsurf is an oral chemotherapy drug. It is designed to treat patients with metastatic colon cancer whose cancer has continued to advance after approved standard therapies. Similar to 5-FU, it works by incorporating itself into the DNA of cancer cells, stopping them from growing.

    FDA APPROVED

    2015

    COMMON SIDE EFFECTS

    • Reduced white blood cells
    • Nausea
    • Vomiting
    • Fatigue
    • Diarrhea

Resources for download


QUESTIONS TO ASK BEFORE TREATMENT

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TREATMENT OPTIONS BY STAGE OF DIAGNOSIS

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METASTATIC TREATMENT OPTIONS

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