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What is a biomarker?


Biomarkers, short for biological markers or molecular markers, have characteristics that enable them to be measured and evaluated as an indicator of normal processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarkers include DNA, proteins, and genetic mutations found in blood, tissue, or other body fluids. Your “biomarker profile” can help you and your doctor personalize your treatment.

Biomarkers for colorectal cancer are used for diagnosis, progression, prognosis, and for treatment. Some biomarkers have both a prognostic and a predictive value.

  • Diagnostic biomarkers detect the disease

  • Prognostic biomarkers are associated with a clinical outcome regardless of the treatment received

  • Predictive biomarkers can predict the benefit or lack of benefit of a treatment

Biomarkers 101

Learn the basics about biomarkers so that you are fully informed on your journey.

BRAF

The BRAF Biomarker and colorectal cancer.

 

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KRAS

The KRAS Biomarker and colorectal cancer.

 

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NRAS

The NRAS Biomarker and colorectal cancer.

 

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HER2

The HER2 Biomarker and colorectal cancer.

 

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NTRK

NTRK Fusions and colorectal cancer.

 

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CEA

The CEA Biomarker and colorectal cancer.

 

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Sidedness

Sidedness and colorectal cancer.

 

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TMB

The TMB Biomarker and colorectal cancer.

 

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MSI-H

The MSI-H Biomarker and colorectal cancer.

 

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MSS

The MSS Biomarker and colorectal cancer.

 

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UGT1A1

The UGT1A1 Biomarker and colorectal cancer.

 

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PIK3CA

The PIK3CA Biomarker and colorectal cancer.

 

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DPYD

The DPYD Biomarker and colorectal cancer.

 

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